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学术文献矩阵

汇集右布洛芬领域的核心临床研究、药理学文献与临床指南

一项右布洛芬和布洛芬的有效性和安全性的系统性评价和荟萃分析

金梦 ¹；陈毓铭 ²；卓瑞洁 ²；邓嫣然 ²；刘微 ¹；张惠静 ²；马乐 ²；甘承 ³；激力杰格⁴；许蓓蓓⁵
2025 药理/药代动力学

Antipyretic Effect of Dexibuprofen Versus Ibuprofen in Children With Fever Caused by Upper Respiratory Tract Infection

C Zhao, L Zhao, J Xie, X Wang, C Li…
2025 儿科用药

Dexibuprofen enteric film-coated tablets: design, characterization and pharmacokinetic analysis in human volunteers

AM Hanif, A Rehman, R Bushra, N Aslam…
2024 药理/药代动力学

Comparative pharmacokinetics and safety studies of dexibuprofen injection and a branded product ibuprofen injection in healthy Chinese volunteers

W Hua, W Zhou, M Su, Q Zhang…
2023 药理/药代动力学

Effectiveness and safety of rectal dexibuprofen versus oral ibuprofen for closure of patent ductus arteriosus in preterm infants with gestational age < 34 weeks

J Pan, Y Yang, S Cui, X Chen…
2023 儿科用药

Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years

VC Ziesenitz, T Welzel, M van Dyk, P Saur, M Gorenflo…
2022 药物安全

Efficacy, Safety, Quality Assurance of Isomers of Non-Steroidal Anti-Inflammatory Drugs: Dexketoprofen and Dexibuprofen

EV Litvinova, MV Zarichkova, OV Posylkina, AG Lisna…
2020 药物安全

The role of dexibuprofen in the treatment of osteoarthritis: pharmacological and clinical aspects

D Fornasari, FA Grassi
2019 骨科用药

Antipyretic efficacy and safety of propacetamol compared with dexibuprofen in febrile children: a multicenter, randomized, double-blind, comparative, phase 3 clinical trial

SJ Choi, S Moon, UY Choi, YH Chun, JH Lee, JW Rhim…
2018 儿科用药

LC-MS/MS 法测定人血浆中布洛芬对映体浓度及其药动学研究

黄明， 张全英， 宗顺麟
2017 药理/药代动力学

Comparison of safety, efficacy and tolerability of dexibuprofen and ibuprofen in the treatment of osteoarthritis of the hip or knee

O Zamani, E Böttcher, JD Rieger, J Mitterhuber…
2014 骨科用药

Pharmacokinetics and bioequivalence of single dose and multiple doses of immediate- and extended-release formulations of dexibuprofen in healthy Chinese volunteers

MJ Xu, C Zou, T Wu, SJ Liu, J Zhang…
2011 药理/药代动力学

Pharmacokinetic Comparison of Controlled- and Immediate-Release Formulations of Dexibuprofen after Single and Multiple Oral Doses in Fasting Healthy Male Volunteers

YH Noh, HS Lim, SH Cho, JL Ghim, S Choe, JA Jung…
2011 药理/药代动力学

Single dose oral dexibuprofen \[S (+)-ibuprofen] for acute postoperative pain in adults (Cochrane Review)

RA Moore, S Derry, HJ McQuay
2009 疼痛管理

The effects and safety of dexibuprofen compared with ibuprofen in febrile children caused by upper respiratory tract infection

JS Yoon, DC Jeong, JW Oh, KY Lee…
2008 儿科用药

Effects of dexibuprofen on platelet function in humans: comparison with low-dose aspirin

JA González-Correa, MM Arrebola, E Martín-Salido…
2007 药理/药代动力学

Enantioselective pharmacokinetics of ibuprofen and involved mechanisms

H Hao, G Wang, J Sun
2005 药理/药代动力学

Dexibuprofen: pharmacology, therapeutic uses and safety

ST Kaehler, W Phleps, E Hesse
2003 药理/药代动力学

Comparative pharmacology of S (+)-ibuprofen and (RS)-ibuprofen

AM Evans
2001 药理/药代动力学

Efficacy and long-term safety of dexibuprofen \[S (+)-ibuprofen]: a short-term efficacy study in patients with osteoarthritis of the hip and a 1-year tolerability study

F Mayrhofer
2001 骨科用药

药理传导时间轴


模拟右布洛芬服用后的吸收、分布与起效全过程
0
min
右布洛芬胶囊口服后，在胃肠道快速崩解释放
S-(+)-布洛芬活性成分直接进入吸收相，无需肝脏首过代谢转化
0
min
血药浓度达峰值时间（Tmax）显著优于普通布洛芬
右旋体生物利用度较外消旋布洛芬提高约 100%，快速抑制 COX-2 酶
0
min
Cmax 达到峰值，抗炎镇痛效应全面释放
精准靶向前列腺素合成通路，有效缓解中重度急性疼痛
0
h
血药浓度维持治疗窗，持续稳定发挥抗炎作用
半衰期约 2 小时，给药间隔 6-8 小时即可维持全天疗效
核心产品

泽芬

® · 右布洛芬胶囊
作为全球 80% 右布洛芬原料药的核心供应方，苏州四药依托手性拆分技术， 推出国内独家产品——泽芬右布洛芬胶囊。精准剔除布洛芬中易引发肠胃不适的左旋成分， 保留 100% 有效右布洛芬，实现 15 分钟快速起效且不伤胃。